Diabetes in HIV Infection: About 22 Cases

Abstract

Objective: to describe the epidemiological-clinical profile of diabetic HIV-positive patients.

Materials and methods: Retrospective study between January 2007 and November 2020 of 22 patients with an HIV-diabetes association and follow-up in the infectious diseases department at the CHU Mohamed VI Marrakech.

Results: in 22 patients with an HIV-diabetes association: The mean age was 45.1 years [31-70 years], Diabetes was diagnosed prior to HIV infection in 72.7% of cases, concurrently with HIV infection in 9.09% of cases, and during follow-up for HIV infection in 18.18% of cases. The clinical signs in patients where the diagnosis of diabetes at the onset or during follow-up of HIV infection were: Asthenia in 33.3% of cases, weight loss in 16.66% of cases, and 50% of patients were asymptomatic. The average blood sugar levels of the patients varied between 1.58 and 3.86 g / l. Patients discovered to have diabetes during follow-up for HIV infection were all on the combination of two nucleotide reverse transcriptase inhibitors (NRTIs) with a non-nucleotide reverse transcriptase inhibitor (NNRTI) in 75% of patients. cases or a protease inhibitor (PI) in 25% of cases.

Conclusion: HIV infection may play a role in increasing the number of people with diabetes, or at least impaired glucose tolerance, due to the side effects of some antiretrovirals (ARVs).Therefore, it is necessary to choose the least toxic ARVs and to detect metabolic abnormalities early. Management should be multidisciplinary