Factors associated with immunovirological discordances, immunological and virological failures in patients living with HIV-1 and followed up at the Bobo-Dioulasso day hospital in 2019.

Abstract

Objective: To determine the prevalence of immunovirological discordance, immunological and virological failures and factors associated in patients living with HIV-1 and followed at the day hospital in Bobo-Dioulasso.
Methods: This descriptive cross-sectional study was conducted from January to December 2019, including HIV-1 human immunodeficiency virus positive patients followed at the adult day hospital in Bobo-Dioulasso and, having received two consecutive measurements of viral load and CD4 T cell count during the year. Data extracted from the evaluation and operational monitoring of ESTHER programs database were analyzed using STATA and SPSS V.20.0.
Results: A total of 261 patients were included in this study. The median age of the study population was 46 ± 10.64 years, with a predominance of the female (70.50%). We noted that 8 patients were in immunological failure (3.06%) with a predominance of married people and subjects aged between 50-59 years. 115 patients had virological failure (44.06%) with a majority of women. The prevalence of immunovirological discordance was (1.92%) with a male predominance (60%). Among the patients with immunovirological discordance, 60 % were between 40-49 years of age and 60 % were married.
Conclusion: The prevalence of virological failures was 44.06% in our study population, those of immunovirological discordance and immunological failures was low, or 1.92% and 3.06% respectively. The main groups encountered in immunovirological discordance and immunological and virological failures in our study population were 40-59 age group, housekeeper, married and not in school