Evaluation of malaria in a randomized child (6 months-6 years) at two different transmission sites in the 2001 season cohort: Sotuba and Donéguébougou in Mali

Abstract

Evaluate the epidemiology of malaria in a cohort of children 6 months to 6 years, randomized living in two villages with different malaria transmission pattern. We conducted a prospective cohort study with a longitudinal follow-up coupled transverse monthly passes on the anti malaria chemoprophylaxis in two different villages. It is an epidemiological study of choice of a potential site for the anti malaria vaccine phase I. Randomization was made on the SPSS software to reset the subjects included in two groups by site. Chemo prophylaxis has been made with the chloroquine + Proguanil (CQ + PG). Were included all subjects aged 6 months to 6 years who reside in the two study sites. The oral consent of parents or guardians is obtained prior to its participation in the study. Are not included all subjects that do not meet the criteria for inclusion in the study, and also volunteers who decide to withdraw from the study. Sex ratio is 1.20 and 1.03 respectively at Donéguébougou and Sotuba for the male in our study population. Plasmodique index does not change significantly (p = 0.50) between the two sites. Splenic index inclusion in December indicates a significant variation between the two sites (p = 0. 0005). This variation is cancels with the introduction of the chemo prophylaxis in the months of August and September. The shielding moved progressively during the other months of follow-up. The incidence of malaria is high Donéguébougou (41.4%) to Sotuba (18.3%). Which is related with the hyper Malaria endemicity of Donéguébougou and meso Sotuba endemic in our study we did had not registered in our cohort of children to the third access to the group under chemo prophylaxis. No child of this group to Sotuba is saved in the Access 2. In the control group two children went to the second access to Donéguébougou against four Sotuba. Children under chemo prophylaxis are fewer Marsh episodes than the control group. The average rate of anthropophilie year .gambiae. Sl to Donéguébougou (92.7%, n = 2390) was comparable to that observed at Sotuba (87.6%, n = 873) for the same vector (p = 0. 000005). Chemoprophylaxis had a significant effect on indices, paludométriques at the level of the two sites. The plasmodique index is significantly different, whereas the average rate of anthropophilie remains similar in the two sites. Donéguébougou might be a good site for vaccine testing of phase I. The year species. gambiae sl, and year. funestus were the main vectors of transmission.