Impact of jet lag in taking of antiretroviral on the viral load among PLHIV followed up in Bamako.

Abstract

Introduction: Adherence has many facets including whom we omissions taken ARVs, interruptions, the lag schedule control. The purpose of this study was to evaluate the impact of jet lag taking ARVs on the evolution of the plasma viral load in patients infected with HIV-1 followed in Bamako (Mali). METHODS: This cross-sectional prospective study in 53 patients with HIV-1 followed in Bamako, ranging from November 2008 to October 2009. Patients were considered adherent if they were good at least taken 95% of their drug without time difference. Results: The frequency of jet lag varied favorably during follow-up: 23 patients at 6 months, 19 cases in 8 months, 16 cases in 10 months, and 9 cases in 12 months. Oblivion was one of the main causes of these time differences, followed by sleep. The difference between changes in viral load (CV) and jet lag at 6 months was significantly (P = 0 .001). The evolution of the CV is probably influenced by the time difference of patients at 12 months (p = 0.07). Of the 41 patients who had undetectable at 12 months CV, 35 or 85.4% were adherent. Conclusion: The time difference seems to have a negative impact on the evolution of the viral load during the first 6 months of treatment. Beyond 6 months of treatment the time difference does not seem to have any effect on viral load.