Study of Adverse effects related to the administration of Sulfadoxine-Pyrimethamine and Amodioquine during chemoprevention of seasonal Malaria Mali
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Abstract
Objective: the occasional preventive treatment defined as the administration of an antimalarial with curative
dose in intervals of predefined a time is a very effective and promising strategy of fight against the malaria. One of the important questions concerning the use of this strategy, is the of the medicinal adverse events, it is in this context that we introduced the present study with as objectives general to study the adverse events bound to the administration of Sulfadoxine-Pyrimethamine and Amodiaquine during Chemoprevention of the seasonal malaria.
Population and Method: Our methodological approach was based on the data collection of the EI through an index card of notification after the administration of the molecules of the Chemoprevention of the seasonal malaria to the children at least of 5ans. The data were collected in the sanitary districts of: Nioro of the Sahel, Nara, Ouelessebougou, Bougouni, Kadiolo, Barouéli, Bla, Segou, Koro, and Tenenkou.
Results: During our study, we registered 131 cases of adverse events presented by 104 children. The sanitary district of Tenenkou registered more case of notification 50 %, followed by Nioro of the Sahel 13 %. In classifying the EI by clinical sign, we found that the digestive disorders were the most represented or 83.2 %. The evolutions of all the EI were favourable.
Conclusion: In the term of this study, can we say that this result does not reflect the reality on the ground with regard to the exhaustiveness of the, he could give some explanation by the sub-notification of the adverse events. So, the strengthening of the system of pharmacovigilance in Mali must be made by the in-service training of the staffs of the health of a continuous notification of the adverse events.