Facteurs de risque de décès par tuberculose pulmonaire bacillifère chez les patients hospitalises au service de pneumo-phtisiologie du Centre hospitalier Universitaire la Référence Nationale (CHU-RN) de N’Djamena

Abstract

Introduction: Tuberculosis remains a major cause of death in the world despite the existence of effective drugs and well codified therapeutic regimens for its treatment. The objective of our study was to describe the profile of patients who died in the pneumophtisiology department of the CHU-RN in order to reduce the mortality rate in the department. Differences in favor of the deceased with p < 0.05

Subjects and Methods: This was a retrospective case-control study of deaths in new cases of smear-positive pulmonary tuberculosis (TPM+) taking one death as the case and the following two new cured TPM+ cases of the same sex of the registry as controls had been carried out over a period of 5 years in the pneumophtisiology department of the NR-UHC of N'Djamena. Were considered as factors linked to death, the variables tested which presented Results: HIV infection was the highest risk factor for death in tuberculosis patients. Patients aged 35 and over, or with cavitary images on X-ray and those with a history of pulmonary tuberculosis had about 2 times the risk of death compared to cured patients. The majority of patients, 65.1%, died during the intensive phase and one in three patients (33.1%) died before the end of the second week. The average delay was 58 days.

Conclusion: Early diagnosis and systematic research of these factors in patients would reduce death rates